منابع مشابه
Chromatin: Packaging without Nucleosomes
Dinoflagellates are unique among eukaryotes in their unusual 'dinokaryons' - nuclei that lack bulk histones. A new study finds that acquisition of a novel dinoflagellate chromatin protein was an early step in the transition to a nucleus lacking detectable nucleosomes.
متن کاملChromatin: Pushing nucleosomes around
In a eukaryotic cell, genomic DNA does not exist in a free state, but is intricately complexed with chromosomal proteins, particularly histones. The basic chromatin fibre consists of an array of nucleosomes, each packaging around 200 base pairs (bp) of DNA; 146 bp is wound around a core of eight histone molecules (two each of H2A, H2B, H3 and H4), with the remaining DNA forming a linker to the ...
متن کاملCharacteristic arrangement of nucleosomes is predictive of chromatin interactions at kilobase resolution
High-throughput chromosome conformation capture (3C) technologies, such as Hi-C, have made it possible to survey 3D genome structure. However, obtaining 3D profiles at kilobase resolution at low cost remains a major challenge. Therefore, we herein present an algorithm for precise identification of chromatin interaction sites at kilobase resolution from MNase-seq data, termed chromatin interacti...
متن کاملChromatin Remodeling: Nucleosomes Bulging at the Seams
ATP-dependent chromatin remodeling enzymes, such as SWI/SNF, hydrolyze thousands of ATPs to regulate gene expression on chromatin fibers. Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states.
متن کاملTranscription of nucleosomes from human chromatin.
Nucleosomes (chromatin subunits) prepared by micrococcal nuclease digestion of human nuclei are similar in histone content but substantially reduced in non-histone proteins as compared to undigested chromatin. Chromatin transcription experiments indicate that the DNA in the nucleosomes is accessible to DNA-dependent RNA polymerase in vitro. The template capacities of chromatin and nucleosomes a...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1978
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/5.11.4431